Presented By: Center for RNA Biomedicine
RNA Innovation Seminar: "Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease"
Wendy Gilbert, Professor, Yale School of Medicine
In-person/Hybrid seminar
Talk title: “Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease"
Keywords: RNA modifications, RNA processing, RNA folding, pre-mRNA, tRNA, translation, cancer
Abstract: RNA modifications are essential for human health—too much or too little leads to serious illnesses ranging from neurodevelopmental disorders to cancer. We are working to uncover the RNA targets of RNA modifying enzymes that are dysregulated in disease and to understand their molecular and organismal roles. Recent advances in detecting the modified nucleosides pseudouridine and dihydrouridine reveal complex landscapes that include pre-messenger RNA and diverse classes of noncoding RNA in yeast and human cells. I will give an update on our progress towards answering three questions: How are specific RNA sites selected for modification and how is this process regulated? What are the molecular consequences of mRNA and non-coding RNA modifications? How do specific defects in RNA metabolism result in organismal phenotypes, including disease?
Brief Bio:
Wendy Gilbert is an Associate Professor of Molecular Biophysics and Biochemistry. Her work focuses on regulatory elements in messenger RNA that control the cellular expression of the information stored in the genetic code. She earned her PhD at UCSF with Christine Guthrie, studying mRNA export and being fascinated by the exquisite mechanisms that couple export-competence to completion of RNA processing. As a postdoc in Jennifer Doudna’s lab at UC Berkeley, she uncovered a non-canonical mechanism of translation initiation. She started her lab at MIT in 2008 and joined the faculty at Yale in 2017. Her lab’s current work ranges widely across RNA biology with the unifying theme of elucidating the molecular mechanisms of RNA regulatory elements controlling mRNA biogenesis, translation and decay. Most recently, this has been in the area of RNA base modification. She was recognized with the RNA Society’s Early Career Award in 2017 for her “paradigm-altering contributions to the field of post-transcriptional gene regulation.”
If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu
Talk title: “Marvelous U: Canonical and non-canonical functions of uridine modifying enzymes in health and disease"
Keywords: RNA modifications, RNA processing, RNA folding, pre-mRNA, tRNA, translation, cancer
Abstract: RNA modifications are essential for human health—too much or too little leads to serious illnesses ranging from neurodevelopmental disorders to cancer. We are working to uncover the RNA targets of RNA modifying enzymes that are dysregulated in disease and to understand their molecular and organismal roles. Recent advances in detecting the modified nucleosides pseudouridine and dihydrouridine reveal complex landscapes that include pre-messenger RNA and diverse classes of noncoding RNA in yeast and human cells. I will give an update on our progress towards answering three questions: How are specific RNA sites selected for modification and how is this process regulated? What are the molecular consequences of mRNA and non-coding RNA modifications? How do specific defects in RNA metabolism result in organismal phenotypes, including disease?
Brief Bio:
Wendy Gilbert is an Associate Professor of Molecular Biophysics and Biochemistry. Her work focuses on regulatory elements in messenger RNA that control the cellular expression of the information stored in the genetic code. She earned her PhD at UCSF with Christine Guthrie, studying mRNA export and being fascinated by the exquisite mechanisms that couple export-competence to completion of RNA processing. As a postdoc in Jennifer Doudna’s lab at UC Berkeley, she uncovered a non-canonical mechanism of translation initiation. She started her lab at MIT in 2008 and joined the faculty at Yale in 2017. Her lab’s current work ranges widely across RNA biology with the unifying theme of elucidating the molecular mechanisms of RNA regulatory elements controlling mRNA biogenesis, translation and decay. Most recently, this has been in the area of RNA base modification. She was recognized with the RNA Society’s Early Career Award in 2017 for her “paradigm-altering contributions to the field of post-transcriptional gene regulation.”
If you are having trouble registering, please contact Martina Jerant at mjerant@umich.edu
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