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Presented By: Functional MRI Lab

Functional MRI 2021-22 Speaker Series with Katharine Thakkar, Ph.D.

Behavioral and Neural Correlates of Rapid Action Modification and Cancellation in Individuals with Schizophrenia and Healthy Controls

Katharine Thakkar, Ph.D. Katharine Thakkar, Ph.D.
Katharine Thakkar, Ph.D.

The ability to make rapid behavioral adjustments is critical in a dynamic environment, and impaired action control is associated with several neuropsychiatric disorders, including schizophrenia. Rapid action modification and cancellation has been investigated using the stop-signal task and related paradigms. These paradigms require a fast response to a movement cue unless a subsequent signal is presented that instructs participants to inhibit or change the planned movement. Performance on these tasks is modeled as a race between competing STOP and GO processes, which permits an estimation of the time it takes to stop a prepared action—stop-signal reaction time. Using oculomotor versions of such tasks, nonhuman primate studies have investigated the cellular basis of reactive action control and performance monitoring. This body of neurophysiology work provides a firm basis from which to understand the brain circuits supporting reactive action control in humans. In this talk, I will present work that uses fMRI to examine the network involved in rapid cancellation, modification, and monitoring of gaze in humans. In addition, I will present a series of studies indicating reduced efficiency of action cancellation in individuals with schizophrenia that are related to symptoms and functional outcomes and more recent work demonstrating altered activation in a frontobasal network in individuals with schizophrenia while performing a modified oculomotor stop-signal task. Combined, this work provides a link between mechanisms of action control in humans and non-human primates and insights into potential mechanisms of inefficient action control in individuals with schizophrenia.

You can attend in person: 4 p.m. Chemistry & Dow Willard H Laboratory (Central Campus), Room 1300.

You can attend via Zoom:,
passcode: 892467
Katharine Thakkar, Ph.D. Katharine Thakkar, Ph.D.
Katharine Thakkar, Ph.D.

Livestream Information

April 12, 2022 (Tuesday) 4:00pm
Meeting ID: 91394388153
Meeting Password: 892467

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