Presented By: Biomedical Engineering
Strategies for finding genes in time-dependent human phenotypes: The genetics of delta-t
BME 500 Seminar - David Burke, Ph.D.
Abstract:
Each person's physiology (phenotype) changes over their lives. While there are common patterns in these changes as we age, there are also significant differences between individuals. Differences in phenotype are dependent on the interaction of the individual's environment and their unique genetic makeup (genotype). What are the genes -- and variants in these genes -- in the human population that impact the variation we see in time-dependent phenotypes? The talk will address the challenges of studying the complexity of human age- and time-dependent (longitudinal) phenotypes. TIme-dependent experimental strategies will require new types of reproducible, non-invasive, quantitative phenotype measurement tools. And, to have a general impact, human measurement technologies should be broadly accessible, particularly to under-served populations. A low-cost, quantitative system for measuring neurological status will be presented as an initial prototype for non-invasive longitudinal phenotype assessment.
Bio:
Dr. Burke is a Professor in the Department of Human Genetics, University of Michigan Medical School. His research centers on developing experimental strategies and technologies for exploring complex, multi-gene genetics in humans. Dr. Burke is interested in understanding the interaction of genetic variation and the environment with chronic, late-life diseases. Before joining the University of Michigan in 1991, he was a post-doctoral fellow in molecular genetics at Princeton University where he studied the laboratory mouse as a model genetic system. Dr. Burke obtained his PhD in the Department of Genetics at Washington University in St. Louis, where he was working on the initial stages of the Human Genome Project. During his time at Michigan, he has worked collaboratively with research groups in the UM College of Engineering, primarily in the area of microfluidics.
Zoom Link: https://umich.zoom.us/j/96508834308
Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering
Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery
Each person's physiology (phenotype) changes over their lives. While there are common patterns in these changes as we age, there are also significant differences between individuals. Differences in phenotype are dependent on the interaction of the individual's environment and their unique genetic makeup (genotype). What are the genes -- and variants in these genes -- in the human population that impact the variation we see in time-dependent phenotypes? The talk will address the challenges of studying the complexity of human age- and time-dependent (longitudinal) phenotypes. TIme-dependent experimental strategies will require new types of reproducible, non-invasive, quantitative phenotype measurement tools. And, to have a general impact, human measurement technologies should be broadly accessible, particularly to under-served populations. A low-cost, quantitative system for measuring neurological status will be presented as an initial prototype for non-invasive longitudinal phenotype assessment.
Bio:
Dr. Burke is a Professor in the Department of Human Genetics, University of Michigan Medical School. His research centers on developing experimental strategies and technologies for exploring complex, multi-gene genetics in humans. Dr. Burke is interested in understanding the interaction of genetic variation and the environment with chronic, late-life diseases. Before joining the University of Michigan in 1991, he was a post-doctoral fellow in molecular genetics at Princeton University where he studied the laboratory mouse as a model genetic system. Dr. Burke obtained his PhD in the Department of Genetics at Washington University in St. Louis, where he was working on the initial stages of the Human Genome Project. During his time at Michigan, he has worked collaboratively with research groups in the UM College of Engineering, primarily in the area of microfluidics.
Zoom Link: https://umich.zoom.us/j/96508834308
Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering
Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery
Livestream Information
ZoomMarch 31, 2022 (Thursday) 3:30pm
Meeting ID: 96508834308
Explore Similar Events
-
Loading Similar Events...
