This talk will focus on part two of a three-part project that considers synergistic integration of potable water reuse and desalination systems. The energy impact of combining reverse osmosis (RO) brine streams and regional brine interceptor/collector streams with wastewater upstream of RO desalination at a potable reuse facility were evaluated. It was found that the percent energy increase in treating high-salinity streams decreases as background wastewater salinity increases; thus, marginal energy consumption is expected to have a decreasing trend in future years.