In this talk Dr. Mavian will present the genomic Real-time High-throughput genomic epidemiology monitoring system that has been developed at University of Florida to track spread, evolution and emergence of new variants in Florida, in collaboration with University of Central Florida and of Miami, and in Haiti in collaboration with GHESKIO. Dr. Mavian will also show the investigations of novel zoonotic coronaviruses that emerged in Haiti and that highlights coronaviruses’ potential for rapid evolution and frequent recombination, leading to periodic emergence of strains capable of crossing species barriers into human populations.