Presented By: Office of Research School of Dentistry
Glucose metabolism in bone biology and diabetic osteopenia
Fanxin Long, PhD William W. Smith Endowed Chair in Pediatric Genomic Research The Children's Hospital of Philadelphia Professor of Orthopedic Surgery University of Pennsylvania
I have been studying skeletal development and homeostasis for over 25 years. I am interested in understanding the molecular and metabolic regulation of skeletal cell types both in the embryo and in adults under normal or pathological conditions. The work has led to new insights into the metabolic features of chondrocytes, osteoblasts and osteoclasts. Studies of Hh, Wnt, Bmp and Notch signaling have uncovered metabolic reprogramming as a common link for developmental signals to regulate the fate and activity of skeletal cells. In a separate line of work, we have sought to elucidate the molecular identify and regulation of mesenchymal stem and progenitor cells in bone. This pursuit has led to the discovery of Gli1+ mesenchymal progenitors as the main source for osteoblasts in growing bones (Shi et al., 2017, Nat Commun., PMC
5725597). More recently, we have demonstrated a critical role for the Gli1+ progenitors in mediating the bone
anabolic role of teriparatide, the main bone anabolic therapy for osteoporosis (Shi et al, 2021, Cell Rep, in
press). The current proposal extends our work on mesenchymal progenitors and builds on the discovery of a
potential adipo-osteoprogenitor in the adult bone marrow. Completion of the proposed study is expected to
uncover the role of the newly discovered progenitors in bone homeostasis, skeletal aging and diabetic
osteopenia.
5725597). More recently, we have demonstrated a critical role for the Gli1+ progenitors in mediating the bone
anabolic role of teriparatide, the main bone anabolic therapy for osteoporosis (Shi et al, 2021, Cell Rep, in
press). The current proposal extends our work on mesenchymal progenitors and builds on the discovery of a
potential adipo-osteoprogenitor in the adult bone marrow. Completion of the proposed study is expected to
uncover the role of the newly discovered progenitors in bone homeostasis, skeletal aging and diabetic
osteopenia.
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