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Presented By: Department of Learning Health Sciences

LHS Collaboratory

"Putting Artificial Intelligence and Machine Learning into Practice: Trustworthiness of Predictions for Individual Patients"

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Ewout W. Steyerberg, PhD
Professor of Clinical Biostatistics & Medical Decision Making, Chair, Dept of Biomedical Data Sciences
Leiden University Medical Center, The Netherlands

Clinical prediction models aim to predict a person’s risk of an outcome (e.g. complications, mortality) given their observed characteristics (1). Risk predictions are traditionally derived from regression models. Artificial Intelligence, and specifically Machine Learning methods, are gaining interest to develop predictive algorithms. Predictions from classic models or AI algorithms need to be reliable to provide valid support for tasks such as shared decision making and whether a person should initiate a particular treatment.
The aim of this talk is to review recent developments in prediction model development and validation. Illustrations will be provided from different medical applications. Trustworthiness will be discussed in relation to the statistical aspects -such as sample size and the exceptionality of patients-, model uncertainty, and heterogeneity between contexts of practical application.

1. Steyerberg EW. Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating. 2nd ed. Springer International Publishing; 2019. (Statistics for Biology and Health). Available from:

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