Talk Title:
Mapping and modulating intercellular signaling in engineered neuromuscular tissues

Abstract:
Human beings and other biological creatures navigate unpredictable and dynamic environments by combining compliant mechanical actuators (skeletal muscle) with neural control and sensory feedback. Abiotic actuators, by contrast, have yet to match their biological counterparts in their ability to autonomously sense and adapt their form and function to changing environments. We have shown that engineered skeletal muscle actuators, controlled by neuronal networks, can generate force and power functional behaviors such as walking and pumping in a range of untethered robots. These muscle-powered robots are dynamically responsive to biochemical and mechanical stimuli and are capable of complex functional behaviors like exercise-mediated strengthening and healing in response to damage. Our lab uses engineered bioactuators as a platform to understand assembly and remodeling in neuromuscular tissues in physiological and pathological states, restore mobility after disease and damage, and power soft robots. This talk will cover the advantages, challenges, and future directions of understanding and manipulating the mechanics of biological motor control.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09

Short Bio:
Ritu Raman, PhD is the d’Arbeloff Career Development Assistant Professor of Mechanical Engineering at MIT. Her lab is centered on engineering adaptive living materials for applications in medicine and machines. Prof. Raman has received several recognitions for scientific innovation, including the NSF CAREER Award, the DoD Army Young Investigator Award, and being named a Kavli Fellow by the National Academy of Sciences. She has also been named to the Forbes 30 Under 30 and MIT Technology Review 35 Innovators Under 35 lists, and is the author of the MIT Press book Biofabrication. She is passionate about increasing diversity in STEM and has championed many initiatives to empower women in science, including being named a AAAS IF/THEN ambassador and founding the Women in Innovation and STEM Database at MIT (WISDM). Prof. Raman received her BS from Cornell University and her PhD as an NSF Graduate Research Fellow at the University of Illinois at Urbana-Champaign. She completed her postdoctoral research with Prof. Robert Langer at MIT, funded by a L’Oréal USA For Women in Science Fellowship and a Ford Foundation Fellowship from the National Academies of Sciences, Engineering, and Medicine.