Presented By: DCMB Seminar Series
Department of Computational Medicine & Bioinformatics -- Weekly Seminar
Presenter: Ravi Allada, M.D., "Why do we sleep? The Circadian and Homeostatic Control of Sleep and Wake"
Abstract:
Why we sleep remains one of the most enduring mysteries in science. Sleep is homeostatically regulated where the duration of wakefulness drives subsequent sleep. Here we aim to determine how waking experience is sensed to trigger sleep and how sleep restores the brain? How does the circadian clock interact with the sleep homeostat? How does impaired sleep lead to human diseases such as Alzheimer’s disease. Our work makes widespread use of -omics approaches including for the identification of diagnostic biomarkers in human sleep disruption.
Short Bio:
Ravi Allada is the Edward C. Stuntz Distinguished Professor of Neuroscience and Chair of the Department of Neurobiology at Northwestern University. Dr. Allada received his M.D from the University of Michigan and completed a residency in Clinical Pathology at the Brigham and Women’s Hospital. During his training, he was an HHMI-NIH Research Scholar and an HHMI Physician Postdoctoral Fellow, the latter with 2017 Nobel Laureate Michael Rosbash. The Allada laboratory has discovered molecule “gears” of the core circadian clock including a link to neurodegenerative disease as well as pathways linking the core clock to daily rhythms of sleep and wake. His laboratory has also identified molecular processes underlying sleep including those linked to memory processing. His work extends discoveries in flies to mammals including the development of diagnostic biomarker signatures for circadian time and examining the effects of jet lag on athletic performance. His work has been funded by the NIH, DARPA as well as private foundations including a Burroughs Wellcome Career Award and a NARSAD Young Investigator Award. He has served as a member of the NIH Sleep Disorders Research Advisory Board and on the Board of Directors as for the Society for Research on Biological Rhythms and Sleep Research Society.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09
Why we sleep remains one of the most enduring mysteries in science. Sleep is homeostatically regulated where the duration of wakefulness drives subsequent sleep. Here we aim to determine how waking experience is sensed to trigger sleep and how sleep restores the brain? How does the circadian clock interact with the sleep homeostat? How does impaired sleep lead to human diseases such as Alzheimer’s disease. Our work makes widespread use of -omics approaches including for the identification of diagnostic biomarkers in human sleep disruption.
Short Bio:
Ravi Allada is the Edward C. Stuntz Distinguished Professor of Neuroscience and Chair of the Department of Neurobiology at Northwestern University. Dr. Allada received his M.D from the University of Michigan and completed a residency in Clinical Pathology at the Brigham and Women’s Hospital. During his training, he was an HHMI-NIH Research Scholar and an HHMI Physician Postdoctoral Fellow, the latter with 2017 Nobel Laureate Michael Rosbash. The Allada laboratory has discovered molecule “gears” of the core circadian clock including a link to neurodegenerative disease as well as pathways linking the core clock to daily rhythms of sleep and wake. His laboratory has also identified molecular processes underlying sleep including those linked to memory processing. His work extends discoveries in flies to mammals including the development of diagnostic biomarker signatures for circadian time and examining the effects of jet lag on athletic performance. His work has been funded by the NIH, DARPA as well as private foundations including a Burroughs Wellcome Career Award and a NARSAD Young Investigator Award. He has served as a member of the NIH Sleep Disorders Research Advisory Board and on the Board of Directors as for the Society for Research on Biological Rhythms and Sleep Research Society.
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09
Related Links
Explore Similar Events
-
Loading Similar Events...
