Presented By: DCMB Seminar Series
DCMB / CCMB Weekly Seminar
Alexandre Marand presents, "An exploration of cis-regulatory diversity in plant single cells"
Abstract:
Each cell of a multicellular organism generally contains the same DNA sequence. Yet, a single organism is composed of hundreds to thousands of highly diverse and functionally unique cell types. This diversification is largely the result of differential gene regulation; distinct cell types express unique sets of genes that encode their identity and dictate their functions. At the forefront of gene regulation are cis-regulatory elements that control “when” and “where” a gene is expressed. Mutations within CREs can perturb the native pattern and magnitude of gene expression and result in drastic molecular, cellular, and morphological phenotypes, including developmental defects in plants and diseases in humans. Until recently, it has been impossible to profile active CREs from diverse plant cell types at scale. I will discuss new efforts to chart cis-regulatory variation within and across several plant species at the level of individual cells and the implication towards phenotypic innovation.
Short Bio:
Dr. Alexandre Marand joined the Department of Molecular, Cellular, and Developmental Biology at the University of Michigan as an Assistant Professor in July of 2023. Dr. Marand obtained his Ph.D. from the University of Wisconsin-Madison in 2018 and was a Postdoctoral Scholar at the University of Georgia from 2018-2023 where he received an NSF Postdoctoral Fellowship in Biology and an NIH Pathway to Independence Award (K99/R00).
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09
Each cell of a multicellular organism generally contains the same DNA sequence. Yet, a single organism is composed of hundreds to thousands of highly diverse and functionally unique cell types. This diversification is largely the result of differential gene regulation; distinct cell types express unique sets of genes that encode their identity and dictate their functions. At the forefront of gene regulation are cis-regulatory elements that control “when” and “where” a gene is expressed. Mutations within CREs can perturb the native pattern and magnitude of gene expression and result in drastic molecular, cellular, and morphological phenotypes, including developmental defects in plants and diseases in humans. Until recently, it has been impossible to profile active CREs from diverse plant cell types at scale. I will discuss new efforts to chart cis-regulatory variation within and across several plant species at the level of individual cells and the implication towards phenotypic innovation.
Short Bio:
Dr. Alexandre Marand joined the Department of Molecular, Cellular, and Developmental Biology at the University of Michigan as an Assistant Professor in July of 2023. Dr. Marand obtained his Ph.D. from the University of Wisconsin-Madison in 2018 and was a Postdoctoral Scholar at the University of Georgia from 2018-2023 where he received an NSF Postdoctoral Fellowship in Biology and an NIH Pathway to Independence Award (K99/R00).
https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09
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