Presented By: DCMB Seminar Series
Gilbert S. Omenn Department of Computational Medicine and Bioinformatics Weekly Seminar Series
Wenbo Li, PhD, "How enhancers work in health and disease? - Views from genetics, epigenetics and epitranscriptomics”
Abstract: Enhancers are crucial genetic elements that control tissue- and cell-type-specific gene expression in metazoans. Omic studies revealed hundreds of thousands of putative enhancers in the human genome, many of which are associated with, and may functionally contribute to, human disease risk. However, the mechanisms underlie enhancer action remain incompletely understood. Dr. Li’s lab focused on using a combination of genetic/epigenome methods to understand the action mechanisms of enhancers and aspire to use these insights to understand human genetics and/or to facilitate disease diagnosis or treatment.
Research Interests:
Genomics, epigenomics, bioinformatics, long noncoding RNAs, enhancer RNAs (eRNAs), enhancers, three-dimensional genome architecture, cohesin and condensin, genomic variations/mutations, RNA binding proteins.
Research Interests:
Genomics, epigenomics, bioinformatics, long noncoding RNAs, enhancer RNAs (eRNAs), enhancers, three-dimensional genome architecture, cohesin and condensin, genomic variations/mutations, RNA binding proteins.
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