Presented By: Department of Human Genetics
Human Genetics Research Seminar Series
presenting Jacy Wagnon, PhD, Assistant Professor Department of Neuroscience The Ohio State University College of Medicine
Monday, April 13, 2026
11:00am - 12:00pm
1020 Kahn Auditorium, BSRB
Jacy Wagnon, PhD
Assistant Professor
Department of Neuroscience
The Ohio State University College of Medicine
“Seminar Title TBD”
Hosted By: Miriam Meisler, PhD, Department of Human Genetics
___
Developmental and epileptic encephalopathies (DEE) are a genetically heterogeneous group of neurological disorders characterized by early-onset seizures along with cognitive, motor, and behavioral impairments. The Wagnon laboratory is interested in understanding genetic and molecular mechanisms underlying DEE and identifying new treatment strategies for these severe disorders. Our current studies focus on DEE caused by variants in the neuronal voltage-gated sodium channel gene SCN8A. We are developing mouse models of SCN8A encephalopathy to study pathogenesis of seizures and related comorbidities. A second focus of the lab is to investigate the role of regulation of gene expression in seizure pathology. Changes in mRNA and microRNA levels represent a general transcriptional response to seizures that may implicate new therapeutic targets.
11:00am - 12:00pm
1020 Kahn Auditorium, BSRB
Jacy Wagnon, PhD
Assistant Professor
Department of Neuroscience
The Ohio State University College of Medicine
“Seminar Title TBD”
Hosted By: Miriam Meisler, PhD, Department of Human Genetics
___
Developmental and epileptic encephalopathies (DEE) are a genetically heterogeneous group of neurological disorders characterized by early-onset seizures along with cognitive, motor, and behavioral impairments. The Wagnon laboratory is interested in understanding genetic and molecular mechanisms underlying DEE and identifying new treatment strategies for these severe disorders. Our current studies focus on DEE caused by variants in the neuronal voltage-gated sodium channel gene SCN8A. We are developing mouse models of SCN8A encephalopathy to study pathogenesis of seizures and related comorbidities. A second focus of the lab is to investigate the role of regulation of gene expression in seizure pathology. Changes in mRNA and microRNA levels represent a general transcriptional response to seizures that may implicate new therapeutic targets.
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