I will discuss the non-perturbative effects from dark matter bound states and their impact on the searches for dark matter. The goal of this talk is to emphasize the importance of dark bound state channels using three examples. I first discuss two dark sector models where the dark matter interacts through a vector or the Higgs portal, and the bound state channels allow indirect detection to explore a much wider range of the parameter space. I also discuss bound state effects on dark matter relic abundance in a co-annihilation model with a top/bottom quark partner.