Presented By: DCMB Seminar Series
DCMB Seminar on Wed 13 Feb || Michael Feig, PhD (Prof. of MSU)
Michael Feig, PhD will present his current research work, "How do biological macromolecules cope with crowding, clustering, phase transitions in cellular environments?
Abstract: Biological macromolecules function in dense, crowded cellular environments. Early studies of crowding effects have emphasized volume exclusion effects, but it is becoming clear that frequent non-specific interactions between proteins, nucleic acids, and metabolites may be the more important factor in modulating the structure and dynamics of biomolecules. Computer simulation studies at different scales of a series of models ranging from concentrated homogeneous protein solutions to models of bacterial cytoplasms are presented to explore the effects of non-specific quinary protein-protein interactions on protein stability and dynamics. One focus is on the formation of transient clusters that determine diffusive properties and lead to liquid-liquid phase transitions. The computational results are related to existing experimental data and the challenges and opportunities to expand the current studies to whole-cell modeling in molecular detail are discussed.
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