DCMB Seminar Series pres.
DCMB Weekly Seminar
Xin He (Assistant Professor, University of Chicago), "Understanding genetics of complex diseases through functional genomics"
The second part of my talk will be focused on genetics of N6-methyladenosine (m6A), a common form of mRNA modification. m6A plays an important role in regulating various aspects of mRNA metabolism in eukaryotes. However, little is known about how DNA sequence variations may affect the m6A modification and the role of m6A in common diseases. We mapped genetic variants associated with m6A levels in 60 Yoruba lymphoblast cell lines. By leveraging these variants, our analysis provides novel insights of mechanisms regulating m6A installation, and downstream effects of m6A on other molecular traits such as translation rate. Integrated analysis with GWAS data reveals m6A variation as an important mechanism linking genetic variations to complex diseases.
BlueJeans livestreaming link: https://primetime.bluejeans.com/a2m/live-event/rbuvycdc
3:45 p.m. - Light Refreshments
4:00 p.m. - Lecture
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