Skip to Content

Sponsors

No results

Tags

No results

Types

No results

Search Results

Events

No results
Search events using: keywords, sponsors, locations or event type
When / Where
All occurrences of this event have passed.
This listing is displayed for historical purposes.

DCMB Seminar Series pres.

DCMB / CCMB Weekly Virtual Seminar - Xiaotian Zhang, Ph.D.

3D Genomics of Normal and Malignant Hematopoiesis

Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
Abstract: The human genome is organized into small compartments to allow for the proper gene expression regulation in the physiological process. With the advance of next-generation sequencing and imaging technologies, we can now investigate how the genome is folded into 3D space and how the 3D genomic organization regulates gene expression in development and disease. Currently, most of the studies are focusing on CTCF and cohesion complex which partner together to facilitate the formation of topological associated domains (TAD). The presenter will mainly discuss his recently published work on the DNA methylation -3D genomics cross-talk. Unpublished work on the 3D genomics in AML will be discussed as well.

Short bio: Xiaotian Zhang obtained his Ph.D. at Baylor College of Medicine with Dr. Margaret Goodell on the role of DNA methylation synergy in leukemia development. He was previously the Van Andel special postdoc fellow in Gerd Pfeifer lab working on the 3D genomics in normal hematopoietic stem cell and leukemia. He is now a Research track faculty (Research Investigator) in Pathology Department under Tomek Cierpicki working on the HOXA regulation in leukemia development. Xiaotian's research focuses on the epigenetic regulation of key pathogenic genes in leukemia, particularly on high order chromatin structure in disease. He published on Nature Genetics, Molecular Cell and Blood as the first author and corresponding authors.

https://umich-health.zoom.us/j/93929606089?pwd=SHh6R1FOQm8xMThRemdxTEFMWWpVdz09
Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
Xiaotian Zhang, Ph.D., Research Investigator in the Department of Pathology at the University of Michigan
Report Event As Inappropriate Contact Event Organizers
Back to Main Content