Skip to Content

Sponsors

No results

Tags

No results

Types

No results

Search Results

Events

No results
Search events using: keywords, sponsors, locations or event type
When / Where
All occurrences of this event have passed.
This listing is displayed for historical purposes.

Presented By: Department of Physics

Physics Graduate Summer Symposium (PGSS) | Improvement of Constant pH Molecular Dynamics on the example of Folate Receptor

Stanislav Cherepanov (UM Biophysics)

Folate receptor is one of the possible targets for anticancer drugs, and this observation is supported by the current use of antifolates in various cancer therapies. In the process of folic acid consumption by a cell, the receptor goes through various stages of endocytosis with changing pH. Moreover, it is known that tumor cells have a more acidic pH than normal cells. However, the pH dependence binding and release of folate and its difference from antifolates is not well understood at this moment. Furthermore, identification of key amino acid residues within folate receptors responsible for the pH-dependent conformational changes observed within the apo and holo-structures of folate receptors will further an effort to design new antifolates with specific properties. Here, we study pKa shifts of amino acids at different stages using Constant pH Molecular Dynamics and their effect on different molecule uptake by the folate receptor.

Explore Similar Events

  •  Loading Similar Events...
Report Event As Inappropriate Contact Event Organizers
Back to Main Content