Presented By: Office of Research School of Dentistry
Understanding Osteoarthritis Pathogenesis using high throughput omic approaches.
Mohit Kapoor, PhD Co-Director, Schroeder Arthritis Institute
Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of
arthritis. Specific mechanisms associated with the joint destruction during OA are largely unknown. Due to the
lack of biomarkers, it is impossible to identify patients exhibiting early stages of OA, leading to severe joint
destruction. Furthermore, due to poor understanding of the underlying disease mechanisms, no approved
disease-modifying therapies to treat OA exist. Therefore, early detection and early intervention is critical to
restore joint functions.
My translational research program is directed towards:
(1) Understanding the complex cellular and molecular mechanisms associated with joint destruction during
osteoarthritis
(2) Identifying reliable biomarkers for early identification of patients with osteoarthritis to enable early
intervention using our large-scale OA biobank that we have created (over 150,000 banked specimens)
(3) Identifying novel therapeutic targets to stop/delay osteoarthritis and restore joint function
arthritis. Specific mechanisms associated with the joint destruction during OA are largely unknown. Due to the
lack of biomarkers, it is impossible to identify patients exhibiting early stages of OA, leading to severe joint
destruction. Furthermore, due to poor understanding of the underlying disease mechanisms, no approved
disease-modifying therapies to treat OA exist. Therefore, early detection and early intervention is critical to
restore joint functions.
My translational research program is directed towards:
(1) Understanding the complex cellular and molecular mechanisms associated with joint destruction during
osteoarthritis
(2) Identifying reliable biomarkers for early identification of patients with osteoarthritis to enable early
intervention using our large-scale OA biobank that we have created (over 150,000 banked specimens)
(3) Identifying novel therapeutic targets to stop/delay osteoarthritis and restore joint function
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